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25, 38 As aberrations in the TP53 gene and t(4:14) translocations are seen in 15% of patients 49 and correlated with short progression-free survival and resistance to alkylating agents at relapse, 50 the ability of BSO to sensitize MM cells with this phenotype suggests that BSO+L-PAM may have clinical activity in the most aggressive forms of MM

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High-risk BCC subtypes included: infiltrative, micronodular, morpheaform, mixed with aggressive subtype (tumour consisting of more than one subtype, of which at least one is an aggressive subtype) and BCC with carcinosarcomatous differentiation